André Machado Xavier

The paper identifies activity-dependent gene programs in human epileptic brain tissue and finds that some responses are conserved with acute stimulation, while others suggest metabolic and inflammatory dysregulation in epilepsy.

The paper identifies two functionally distinct inflammatory microglial states in mice associated with demyelination and shows how signaling and epigenomic mechanisms drive their transcriptional reprogramming.

The paper presents a single-nucleus RNA-sequencing dataset of mouse visual cortex cells under sensory deprivation or stimulation, identifying 1,268 sensory-induced genes and their functional roles in neural circuit development.

The paper describes two methods to quantify synapse engulfment by OPCs, combining in vivo imaging and flow cytometry for high-throughput analysis.

This study identifies signaling and epigenomic mechanisms regulating microglia inflammatory activity through multi-omics analyses of gene expression, chromatin accessibility, and transcription factor activity in acute and chronic brain pathologies.

This study identifies transcriptional mechanisms regulating microglial proliferation in development and disease models, revealing two modes of gene regulation.