Serge Rivest

The paper identifies two functionally distinct inflammatory microglial states in mice associated with demyelination and shows how signaling and epigenomic mechanisms drive their transcriptional reprogramming.

This study identifies signaling and epigenomic mechanisms regulating microglia inflammatory activity through multi-omics analyses of gene expression, chromatin accessibility, and transcription factor activity in acute and chronic brain pathologies.

This study identifies transcriptional mechanisms regulating microglial proliferation in development and disease models, revealing two modes of gene regulation.