Sara Bitarafan

The paper identifies novel Kv1.3 channel-interacting proteins in T-cells using proximity labeling, revealing interactions with immune signaling and trafficking machinery, and links some interactors to autoimmunity risk.

A feature learning model identifies cytokine profiles and signaling pathways predictive of mesenchymal stromal cell therapeutic efficacy in a rat osteoarthritis model.

The paper identifies two functionally distinct inflammatory microglial states in mice associated with demyelination and shows how signaling and epigenomic mechanisms drive their transcriptional reprogramming.

This study shows that AV flicker at specific frequencies can mitigate stress-induced changes in mice, with 10Hz effective in males and 40Hz in females.

This paper demonstrates that MSC-EVs modulate microglia morphology and cytokine secretion, suggesting their therapeutic potential for neuroinflammation, and introduces a high-throughput morphological screening method for EV bioactivity.

The paper investigates how different frequencies and durations of sensory flicker affect transcriptional profiles in 5xFAD mice, showing frequency- and duration-specific changes in immune, neuronal, and metabolic genes.

This study shows that specific brain rhythms alter microglial morphology and cytokine expression through NFkappaB signaling, with frequency-specific effects observed in healthy animals.

This study examines how repeated mild traumatic brain injuries affect the brain in 3xTg mice, identifying sex-specific changes in gene expression and immune responses.

The paper uses TurboID-NES to profile proteomes of microglial and neuronal cell lines, showing it captures a significant portion of the proteome and responds to LPS treatment.

This study identifies signaling and epigenomic mechanisms regulating microglia inflammatory activity through multi-omics analyses of gene expression, chromatin accessibility, and transcription factor activity in acute and chronic brain pathologies.