David Gosselin

The paper identifies two functionally distinct inflammatory microglial states in mice associated with demyelination and shows how signaling and epigenomic mechanisms drive their transcriptional reprogramming.

This study identifies a senescent-like phenotype in neurons under inflammation and shows that rejuvenation improves survival in an MS model.

This study identifies immune gene expression signatures in neurons from MS patients and EAE mice, revealing shared pathways and potential roles for IRF5 and STAT1 in neuronal inflammation.

This study identifies signaling and epigenomic mechanisms regulating microglia inflammatory activity through multi-omics analyses of gene expression, chromatin accessibility, and transcription factor activity in acute and chronic brain pathologies.

This study identifies transcriptional mechanisms regulating microglial proliferation in development and disease models, revealing two modes of gene regulation.

The paper identifies cell type-specific enhancer-promoter connectivity in the human brain and links these to disease risk variants in Alzheimer's and psychiatric disorders.