Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency
Paige N Canova, Sarah Katzenell, Stacey Cerón, Audra J. Charron, Jean M. Pesola, Hyung Suk Oh, Donald M. Coen, David M. Knipe, David A. Leib
This study shows ICP34.5 sustains HSV-1 latency in human neurons by maintaining host translation, with distinct mechanisms in human iPSC-derived neurons versus mouse primary neurons.
bioRxiv · Apr 4, 2025 · PreprintImmunology