Author

David M. Knipe

Harvard UniversityORCID 0000-0003-1554-6236Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

David M. Knipe1 paper

Biology Disciplines

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Immunology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Hyung Suk OhiD· 3 shared Adrian R. OrszulakiD· 1 shared Ahmet Buğra TufaniD· 1 shared Aimee J. AylwardiD· 1 shared Audra J. CharroniD· 1 shared Benjamin P. Readhead· 1 shared David A. LeibiD· 1 shared Donald M. CoeniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

Hyung Suk OhORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 29, 2026

Structures of MyD88 and its oncogenic mutant reveal DNA binding with implications for cytosolic DNA sensing

Pietro Fontana, Ahmet Buğra Tufan, Patrick Günther…·Hao Wu

This study reveals the structure of MyD88 and its oncogenic mutant, showing direct DNA binding and its role in innate immune responses.

DOI 10.64898/2026.10.21.760499

humanprotein structure

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Genomicsnpj DementiaPeer-reviewedMar 9, 2026

Development of a high-throughput, quantitative platform using human cerebral organoids to study virus-induced neuroinflammation in Alzheimer's disease

Meagan N. Olson, Pepper Dawes, Liam F. Murray…·Elaine T. Lim

This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.

8 citationstop 1%

humanexperimental assay

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ImmunologybioRxivPreprintApr 4, 2025

Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency

Paige N Canova, Sarah Katzenell, Stacey Cerón…·David A. Leib

This study shows ICP34.5 sustains HSV-1 latency in human neurons by maintaining host translation, with distinct mechanisms in human iPSC-derived neurons versus mouse primary neurons.

1 citation

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