Author

Donald M. Coen

Harvard UniversityORCID 0000-0002-2148-5671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Jean M. PesolaiD· 2 shared Audra J. CharroniD· 1 shared Biswajit DasiD· 1 shared Carly A. BobakiD· 1 shared Chenggong JiiD· 1 shared Cong LiuiD· 1 shared David A. LeibiD· 1 shared David M. KnipeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

Jean M. PesolaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance

Pierce Longmire, Han Chen, David R. McKinzey, Mamata Savanagouder, Noelle N. Kosarek, Jean M. Pesola, Carly A. Bobak, Giovanni Bosco, Goodrum Felicia, Donald M. Coen

This study identifies host DNA repair factors that enable antiviral nucleoside analog resistance by facilitating viral DNA synthesis in the presence of ganciclovir.

Proceedings of the National Academy of Sciences · Aug 17, 2026Peer-reviewedMicrobiology

Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly

Zishuo Yu, Pradeep Sathyanarayana, Cong Liu, Joel M. J. Tan, Pan pan Yang, Biswajit Das, Side Hu, Xiaoyi Fan, Chenggong Ji, Sandra K. Weller, Mrinal Shekhar, Donald M. Coen, Philip J. Kranzusch, Joseph J. Loparo, Jonathan Abraham

This study determines the structure of HSV-1 helicase-primase inhibited by HPIs and reveals how it interacts with the replication fork complex.

Cell · Dec 29, 2025Peer-reviewedMicrobiology

Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency

Paige N Canova, Sarah Katzenell, Stacey Cerón, Audra J. Charron, Jean M. Pesola, Hyung Suk Oh, Donald M. Coen, David M. Knipe, David A. Leib

This study shows ICP34.5 sustains HSV-1 latency in human neurons by maintaining host translation, with distinct mechanisms in human iPSC-derived neurons versus mouse primary neurons.

bioRxiv · Apr 4, 2025 · PreprintImmunology