Analysis of the phosphorylation networks characterizing distinct phenotypic states in glioblastoma cell Populations
Januka Khanal, Chunxiao Ren, Wenue Li, Tatsuya Matsubara, Jihoon Lee, Deok‐Ho Kim, Jennifer A. Moliterno, Murat Günel, Sergei Kotelnikov, Stan Xiaogang Li, Ernest Glukhov, Dima Kozakov, Yansheng Liu, Andre Levchenko
The paper identifies phenotype-specific signaling networks in glioblastoma cells, showing that invasive spread is linked to DNA damage response and AKT-mTOR activation, with 14-3-3 proteins mediating phosphorylation and predictive phospho-site signatures for patient survival.
bioRxiv · Aug 22, 2025 · PreprintSystems Biology