Templating and confining calcium phosphate mineralization within designed protein assemblies
Le Tracy Yu, Xinqi Li, Harley Pyles, Anjali P. Patni, Andrew J. Borst, Neville P. Bethel, Paul S. Kwon, Connor Weidle, Ryan D. Kibler, Kenneth D. Carr, Yulai Liu, Dongsheng Li, Stanislav Moroz, Hannele Ruohola‐Baker, Shuai Zhang, , David A. Baker
This study shows that computationally designed proteins can template and confine hydroxyapatite mineralization, providing a framework for programmable protein-guided mineralization.
bioRxiv · Jul 8, 2026 · PreprintBiochemistry