Cofilin loss in Drosophila muscles contributes to myopathy through defective sarcomerogenesis
Mridula Balakrishnan, Shannon F. Yu, Samantha M. Chin, David B. Soffar, Stefanie E. Windner, Bruce L. Goode, Mary K. Baylies
This study shows that loss of Drosophila Cofilin disrupts sarcomere structure and function, leading to myopathy, and that proteasome activation can delay muscle deterioration.
bioRxiv · Oct 31, 2019 · PreprintDevelopmental Biology