The Shigella E3 ubiquitin ligase IpaH7.8 reprograms host kinase signaling to suppress NOX2-dependent oxidative burst responses in human monocytes
Theresa Karagöz, Ivan Ngueya Yango, Stefanie Norkowski, Yannick Teschke, Britta Körner, Joyleen M Fernandes, Yvonne Boergeling, Petra Dersch, Christian Rüter
This paper shows that IpaH7.8, a Shigella effector, enters human cells without a secretion system, suppresses inflammasome activity, and reprograms kinase signaling to inhibit oxidative burst responses.
bioRxiv · May 1, 2026 · PreprintMicrobiology