Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis
Paul-Lennard Mendez, Lion VA Raaz, Jerome Jatzlau, Yunyun Xiao, Pieter Vrancaert, Jakub Ksiazkiewicz, Jakob Wallentin, Michael Trumpp, Stefanie Scharnitzki, Stefan Mundlos, Aernout Luttun, An Zwijsen, Fumiko Itoh, Petra I. Knaus
This study identifies SMAD/FOXO1 complexes that mediate EndoMT in response to atheroprone flow, showing their role in atherosclerosis and suggesting targeting this interaction could reduce disease progression.
bioRxiv · Nov 25, 2024 · PreprintGenomics