Aernout Luttun

Matrix stiffness shifts the endothelial shear stress set point for angiogenic activation

This paper investigates how matrix stiffness and shear stress jointly influence endothelial gene expression and angiogenic activation thresholds using transcriptomics.

Defining the Vascular Niche of Human Adipose Tissue Across Metabolic States

The paper creates a single-cell transcriptome atlas of human subcutaneous adipose tissue vascular cells, identifies sub-AdECs, and links their properties to metabolic disease.

Prdm16 amplifies Notch signaling and suppresses venous lineage specification to prevent arteriovenous malformations during vascular development

This study shows Prdm16 enhances Notch signaling in arterial endothelial cells and suppresses venous fate to prevent arteriovenous malformations in zebrafish and human cells.

Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis

This study identifies SMAD/FOXO1 complexes that mediate EndoMT in response to atheroprone flow, showing their role in atherosclerosis and suggesting targeting this interaction could reduce disease progression.

Autologous micrograft accelerates endogenous wound healing response via ERK-induced cell migration

This study shows that autologous micrograft therapy accelerates wound healing by enhancing fibroblast migration through ERK pathway activation and increased matrix metalloproteinase activity.