Author

Fumiko Itoh

Tokyo University of Pharmacy and Life SciencesORCID 0000-0002-6134-5331Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aernout LuttuniD· 1 shared An ZwijseniD· 1 shared Hirokazu KajiiD· 1 shared Jakob WallentiniD· 1 shared Jakub KsiazkiewicziD· 1 shared Jerome JatzlauiD· 1 shared Kao Tsuchiya· 1 shared Kazuki TAKAHASHIiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Aernout LuttunORCID

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2 papers

Recent·Most cited

Three-dimensional vascular microenvironments uncover endothelial plasticity during TGF-β2-driven vascular remodeling

Yuning Fu, Kao Tsuchiya, Yuji Nashimoto, Kazuki TAKAHASHI, Yujin Ohsugi, Sayaka Katagiri, Takeshi Hori, Miho Kobayashi, Shotaro Yoshida, Fumiko Itoh, Tetsuro Watabe, Hirokazu Kaji

This study shows that TGF-β2 induces endothelial plasticity and EndoMT in 3D vascular networks, revealing distinct responses compared to 2D cultures.

bioRxiv · Aug 5, 2026 · PreprintBioengineering

Atheroprone Flow Activates SMAD-FOXO1 to drive Endothelial-to-Mesenchymal Transition and Atherosclerosis

Paul-Lennard Mendez, Lion VA Raaz, Jerome Jatzlau, Yunyun Xiao, Pieter Vrancaert, Jakub Ksiazkiewicz, Jakob Wallentin, Michael Trumpp, Stefanie Scharnitzki, Stefan Mundlos, Aernout Luttun, An Zwijsen, Fumiko Itoh, Petra I. Knaus

This study identifies SMAD/FOXO1 complexes that mediate EndoMT in response to atheroprone flow, showing their role in atherosclerosis and suggesting targeting this interaction could reduce disease progression.

bioRxiv · Nov 25, 2024 · PreprintGenomics