Robust de novo design of protein binding proteins from target structural information alone
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel R. Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, , David A. Baker
This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.
bioRxiv · Sep 4, 2021 · PreprintSynthetic Biology