Author

Kenneth Verstraete

Ghent UniversityORCID 0000-0001-6544-6458Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Koen H. G. VerschuereniD· 3 shared Savvas N. SavvidesiD· 3 shared Brian CoventryiD· 2 shared Buwei HuangiD· 2 shared David A. BakeriD· 2 shared Hannele Ruohola‐BakeriD· 2 shared Inna GoreshnikiD· 2 shared Iva MarkovićiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiochemistry

Koen H. G. VerschuerenORCID

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3 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJan 10, 2026

✦ In-depth digest

Improved protein binder design using -pairing targeted RFdiffusion

Isaac Sappington, Martin Toul, David S. Lee…·David A. Baker

Conditioning RFdiffusion on edge beta-strand pairing yields specific binders to polar targets, with in silico success above 9.2% versus 0.98% for hotspot-only conditioning.

33 citationstop 1%

protein structurestructural biology

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedMar 23, 2023

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Alexandra Tsirigotaki, Ann Dansercoer, Koen H. G. Verschueren…·Kenneth Verstraete

This study reveals the structure and mechanism of Leptin-mediated LEP-R assembly, showing a 3:3 stoichiometry and highlighting the role of Leptin restructuring in activating signaling.

29 citationstop 5%

humanproteomics

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Synthetic BiologybioRxivPreprintSep 4, 2021

Robust de novo design of protein binding proteins from target structural information alone

Longxing Cao, Brian Coventry, Inna Goreshnik…·David A. Baker

This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.

12 citations

protein structureexperimental assay

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