Iva Marković

This paper introduces EvolveX, a computational pipeline for designing stable single-domain antibodies with high affinity, demonstrating improved binding affinity to human targets.

This study reveals the structure and mechanism of Leptin-mediated LEP-R assembly, showing a 3:3 stoichiometry and highlighting the role of Leptin restructuring in activating signaling.

This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.