Kevin M. Jude

MHC restriction is structurally encoded by the T cell receptor germline

The paper shows that TCR germline sequences encode MHC restriction, revealing a structural basis for TCR recognition of MHC molecules independent of antigenic peptide.

Structural basis of stepwise G protein activation by the viral chemokine receptor US28

The paper determines structural states of the US28-Gq complex to elucidate a stepwise G protein activation mechanism.

A Cytokine Receptor Signaling Atlas Reveals How STAT Mosaics Fine-Tune T Cell Function

A fully orthogonal IL-2 receptor platform isolates 36 cytokine receptors in T cells; receptor-specific STAT combinations specify distinct fates, and STAT3-dominant programs give curative antitumor responses.

Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy

This study develops a receptor-tethered orthogonal IL-2 system to enhance Treg persistence and efficacy in autoimmune diabetes, showing improved survival and therapeutic outcomes.

Design of solubly expressed miniaturized SMART MHCs

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy

The paper shows that T cells engineered with IL-9R have better tissue infiltration, stemness, and anti-tumor activity compared to those with an orthogonal IL-9 receptor, due to stronger and more specific JAK/STAT signaling.

Targeting peptide-MHC complexes with designed T cell receptors and antibodies

This paper introduces ADAPT, a deep learning framework for designing TCRs and antibodies that bind to specific pMHC targets, validated through cryo-EM structures and functional testing.

Potent antitumor activity of a designed interleukin-21 mimic

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.

De novo design and structure of a peptide-centric TCR mimic binding module

A de novo four-helix bundle designed with RFdiffusion and ProteinMPNN binds NY-ESO-1/HLA-A*02 at Kd 9.5 nM, with a 2.05 Å crystal structure and peptide-focused docking.

Robust de novo design of protein binding proteins from target structural information alone

This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.