Author

Lisa Kozodoy

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

David A. BakeriD· 3 shared Inna GoreshnikiD· 3 shared Lance J. StewartiD· 3 shared Longxing CaoiD· 3 shared Alexandra C. WallsiD· 2 shared Brian CoventryiD· 2 shared David VeesleriD· 2 shared Eva‐Maria StrauchiD· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSynthetic Biology

David A. BakerORCID

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Author profile →

3 papers

Recent·Most cited

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

Andrew C. Hunt, James Brett Case, Young‐Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Andy Hsien-Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien-Ying Hsiang, Tyler N. Starr, Inna Goreshnik, , David A. Baker

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

Science Translational Medicine · Apr 12, 2022Peer-reviewedSynthetic Biology

Robust de novo design of protein binding proteins from target structural information alone

Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel R. Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, , David A. Baker

This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.

bioRxiv · Sep 4, 2021 · PreprintSynthetic Biology

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

Longxing Cao, Inna Goreshnik, Brian Coventry, James Brett Case, Lauren Miller, Lisa Kozodoy, Rita E. Chen, Lauren P. Carter, Alexandra C. Walls, Young‐Jun Park, Eva‐Maria Strauch, Lance J. Stewart, Michael Diamond, David Veesler, David A. Baker

The paper designs picomolar SARS-CoV-2 miniprotein inhibitors using computational methods and experimental validation, showing high potency and structural similarity to computational models.

Science · Sep 9, 2020Peer-reviewedSynthetic Biology