BRD1 haploinsufficiency disrupts neurodevelopmental and metabolic homeostasis in a translational minipig model
Julie Grinderslev Donskov, Tue Fryland, Bolette Hestbek Nicolaisen, Sanne Hage la Cour, Paula Rodrigo Martin, Steffi Pauwels, Lina Zühlsdorf, Dimitrios Pediotidis-Maniatis, Jacob Egemose Høgfeldt, Arne Mørk, Jane Christensen, Ida E. Holm, Gregers Wegener, Simon Fristed Eskildsen, Torben E. Lund, , Per Qvist
This study shows that reduced BRD1 function in minipigs leads to coordinated neurodevelopmental and metabolic changes in both brain and peripheral tissues.
bioRxiv · Oct 21, 2025 · PreprintGenetics