Per Qvist

BRD1 haploinsufficiency alters early neuronal programming and disrupts maturation in human induced glutamatergic neurons

This study shows BRD1 haploinsufficiency disrupts early neuronal programming and synaptic maturation in human induced glutamatergic neurons, leading to altered neurodevelopmental trajectories and increased neuronal activity.

BRD1 haploinsufficiency disrupts neurodevelopmental and metabolic homeostasis in a translational minipig model

This study shows that reduced BRD1 function in minipigs leads to coordinated neurodevelopmental and metabolic changes in both brain and peripheral tissues.

A triple serine motif in the intracellular domains of sortilin-related receptors SorCS1-3 regulates neurotrophic activity

This study identifies a triple serine motif in SorCS1-3 intracellular domains that regulates neurotrophic signaling through phosphorylation, leading to CREB activation and BDNF pathway modulation.

Psychometric archetypes reveal biological signatures of vulnerability, resilience, and future mental health

The paper identifies psychometric archetypes in young adults that correlate with biological markers of mental health vulnerability and resilience, improving predictive models for clinical outcomes.

APP and its intracellular domain modulate Alzheimers disease risk gene networks in transgenic APPsw and PSEN1M146I porcine models

This study uses transgenic porcine models to show that APP and its AICD domain modulate AD-related gene networks through interactions with signaling proteins.

Enhanced Production of Mesencephalic Dopaminergic Neurons from Lineage-Restricted Human Undifferentiated Stem Cells

This study genetically modifies human pluripotent stem cells to generate lineage-restricted undifferentiated stem cells that efficiently produce mesencephalic dopaminergic neurons for potential clinical applications.

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbidities

This study identifies 64 new risk loci for major depression, refines its genetic architecture, and shows strong genetic overlap with other psychiatric disorders and educational attainment.

Sorting receptor SORCS2 facilitates a protective stress response in pancreatic islets

This study identifies SORCS2's role in pancreatic islet stress response, showing its importance in glucose-stimulated insulin release and metabolic health.

SorCS2 binds progranulin and regulates motor axon outgrowth

This study identifies SorCS2 as a receptor for progranulin that regulates motor axon outgrowth in zebrafish and mice, with loss-of-function phenotypes observed in both species.

Common risk variants identified in autism spectrum disorder

This study identifies five genome-wide significant loci and seven shared with other traits in a large ASD GWAS, highlighting polygenic heterogeneity and the value of large-scale GWAS in ASD.

Genome-wide association study implicates CHRNA2 in cannabis use disorder

This paper identifies a genome-wide significant risk locus for cannabis use disorder, implicating CHRNA2 and linking it to cognitive performance.

The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders

This study investigates the role of BRD1 in sex-biased nuclear receptor signaling and its implications in mental disorders using mouse models and gene expression analysis.