Humanized tau and amyloid-β deposition accelerate tau propagation, neuronal cell loss and neurophysiological dysfunction in novel mouse models of primary age-related tauopathy and Alzheimer's disease
Arun Reddy Ravula, Ayaka Hagita-Tatsumoto, Brendan J. Gibbs, Nibedita Basu Ray, J. W Ellison, Alejandro Longtree‐Preciado, Stephanie Radhakishun, Wenhui Qiao, Na Zhao, Takashi Saito, Seiko Ikezu, Tsuneya Ikezu
This study shows that human tau and amyloid-β pathology alter tau propagation patterns and cause neurophysiological dysfunction in mouse models of tauopathy and Alzheimer's disease.
bioRxiv · Feb 24, 2026 · PreprintNeuroscience