Seiko Ikezu

This study shows that human tau and amyloid-β pathology alter tau propagation patterns and cause neurophysiological dysfunction in mouse models of tauopathy and Alzheimer's disease.

This study shows that tau propagation from entorhinal cortex to hippocampal CA1 neurons leads to sex-specific cognitive and electrophysiological impairments, driven by distinct neuroimmune responses in males and females.

This study shows that inhibiting CSF1R in male MIA offspring improves sociability and memory, while female offspring show no improvement, highlighting sex-specific therapeutic potential.

The paper characterizes neuronal extracellular vesicle interactomes in Alzheimer's disease mouse models using TurboID-based proximity labeling and identifies disease-associated proteins.

The paper shows that amyloid plaques accelerate tau propagation in mice by activating microglia, which secrete more extracellular vesicles.

The paper identifies enriched neurodegenerative microglia signatures in EVs from Alzheimer's disease mouse models using proteomic analysis.

This study investigates how Alzheimer's disease-derived extracellular vesicles propagate tau pathology and affect GABAergic neuronal transmission.

This study shows that TTBK1 and Aβ synergistically induce CRMP2 phosphorylation, leading to neurite degeneration and pTau accumulation in AD mouse models.