Tsuneya Ikezu

Humanized tau and amyloid-β deposition accelerate tau propagation, neuronal cell loss and neurophysiological dysfunction in novel mouse models of primary age-related tauopathy and Alzheimer's disease

This study shows that human tau and amyloid-β pathology alter tau propagation patterns and cause neurophysiological dysfunction in mouse models of tauopathy and Alzheimer's disease.

Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory

This study shows that tau propagation from entorhinal cortex to hippocampal CA1 neurons leads to sex-specific cognitive and electrophysiological impairments, driven by distinct neuroimmune responses in males and females.

Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor

This study shows that inhibiting CSF1R in male MIA offspring improves sociability and memory, while female offspring show no improvement, highlighting sex-specific therapeutic potential.

Proteomic characterization of neuronal extracellular vesicle interactomes in Alzheimer's disease mouse model through TurboID-based proximity labeling

The paper characterizes neuronal extracellular vesicle interactomes in Alzheimer's disease mouse models using TurboID-based proximity labeling and identifies disease-associated proteins.

Protein phosphatase 2A, complement component 4, and APOE genotype linked to Alzheimer disease using a systems biology approach

This paper identifies PPP2CB and C4B as key genes linked to Alzheimer's disease through a systems biology approach, showing their association with tau pathology and complement pathway activation.

Integrative Brain Transcriptome Analysis Links Complement Component 4 and HSPA2 to the APOE ε2 Protective Effect in Alzheimer Disease

The paper identifies a co-expression network involving C4A, C4B, and HSPA2 linked to APOE ε2's protective effect against Alzheimer's disease, primarily associated with tau pathology.

Amyloid plaque deposition accelerates tau propagation via activation of microglia in a humanized APP mouse model

The paper shows that amyloid plaques accelerate tau propagation in mice by activating microglia, which secrete more extracellular vesicles.

Enrichment of neurodegenerative microglia signature in brain-derived extracellular vesicles isolated from Alzheimer's disease mouse model

The paper identifies enriched neurodegenerative microglia signatures in EVs from Alzheimer's disease mouse models using proteomic analysis.

Alzheimer's disease brain-derived tau-containing extracellular vesicles: Pathobiology and GABAergic neuronal transmission

This study investigates how Alzheimer's disease-derived extracellular vesicles propagate tau pathology and affect GABAergic neuronal transmission.

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

This study shows that TTBK1 and Aβ synergistically induce CRMP2 phosphorylation, leading to neurite degeneration and pTau accumulation in AD mouse models.