Ayaka Hagita-Tatsumoto

This study shows that human tau and amyloid-β pathology alter tau propagation patterns and cause neurophysiological dysfunction in mouse models of tauopathy and Alzheimer's disease.

This study identifies the S/P region of MAP2 as critical for its localization in dendrites, revealing that cytoplasmic dynein-mediated transport maintains this localization through an intermittent active transport mechanism.