A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model.
Anna Pons-Grífols, Ferran Tarrés-Freixas, Mónica Pérez, Eva Riveira‐Muñoz, Dàlia Raïch Regué, Daniel Perez‐Zsolt, Jordana Muñoz‐Basagoiti, Barbara Tondelli, Edwards Pradenas, Nuria Izquierdo‐Useros, Sara Capdevila, Júlia Vergara‐Alert, Víctor Urrea, Jorge Carrillo, Ester Ballana, , Julià Blanco
This paper introduces a knock-in mouse model for SARS-CoV-2 infection that replicates respiratory issues but avoids neurological disease seen in the K18-hACE2 model.
mBio · Apr 24, 2025Peer-reviewedMicrobiology