Ancient gene clusters govern the initiation of monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion
Jaewook Hwang, Jonathan Kirshner, Daniel André Ramey Deschênes, Matthew Bailey Richardson, Steven J. Fleck, Scott Galeung Alexander Mann, Jun Guo, Jacob Owen Perley, Mohammadamin Shahsavarani, Jorge Jonathan Oswaldo Garza‐García, Alyssa Dawn Seveck, Savannah Sadie Doiron, Zhan Mai, Stephen Nelson Silliphant, Sarah A. Englehart, , Yang Qu
This study identifies and characterizes a conserved oxidase-reductase pair responsible for C3 stereochemistry inversion in monoterpenoid indole alkaloids and traces the evolutionary origin of the gene clusters involved.
Nature Communications · Nov 25, 2025Peer-reviewedBiochemistry