Author

Steve D.M. Brown

Mary Lyon Centre at MRC Harwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Need· 1 shared A. Rendon· 1 shared A. Siddiq· 1 shared Andrew D. DevereauiD· 1 shared Andrew J. ParkeriD· 1 shared Angela D. HambliniD· 1 shared Ann Marie FlennikeniD· 1 shared Ann‐Marie MalloniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenomics

A. C. Need

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2 papers

Recent·Most cited

CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern

Arnaud P. J. Giese, Andrew J. Parker, Sakina Rehman, Steve D.M. Brown, Saima Riazuddin, Craig W. Vander Kooi, Michael R. Bowl, Zubair M. Ahmed

The paper investigates the distinct roles of CIB2 and whirlin in cochlear stereocilia development and shows that CIB2 has independent functions from whirlin in maintaining the staircase pattern.

Disease Models & Mechanisms · Mar 1, 2025Peer-reviewedNeuroscience

Human and mouse essentiality screens as a resource for disease gene discovery

Pilar Cacheiro, Violeta Muñoz‐Fuentes, Stephen A. Murray, Mary E. Dickinson, Maja Bućan, Lauryl M. J. Nutter, Kevin A. Peterson, Hamed Haselimashhadi, Ann Marie Flenniken, Hugh Morgan, Henrik Westerberg, Tomasz Konopka, Chih‐Wei Hsu, Audrey E. Christiansen, Denise Grant Lanza, , A. Siddiq

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

Nature Communications · Jan 31, 2020Peer-reviewedGenomics