Lauryl M. J. Nutter

This study uses a Rosella-PLIN2 biosensor to track lipophagy in atherosclerosis, revealing cell-specific differences in lipid metabolism and immunometabolic interactions.

This study shows that tau deletion enhances synaptic weakening in male rats but not females, revealing sex-dependent effects on synaptic function and actin dynamics.

This study shows that crispant founder mice can be used for phenotypic assessment despite genetic mosaicism, as observed null phenotypes were present in up to 100% of founders.

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

The paper analyzes whole-genome sequencing data from Cas9-edited mice to assess off-target mutagenesis, finding minimal off-target activity across 163 guide RNAs.

The paper identifies novel Mendelian genes by analyzing mouse embryo lethality and linking them to human disease phenotypes and genetic variants.

This study identifies subtle cardiac abnormalities in ASD mouse models, highlighting heterogeneity and potential shared mechanisms with CHD.

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

This study investigates the effects of Arid1b haploinsufficiency in mice, revealing sex-dependent neuroanatomical and behavioral phenotypes associated with neurodevelopmental disorders.

The paper reports on the occurrence of tarsal injuries in male C57BL/6N mice across multiple international facilities, describing clinical signs and findings from radiographic and histological analyses.

FORCAST is a software pipeline that integrates existing tools to design, evaluate, and store Cas-mediated mutagenesis experiments.

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

The paper provides a metabolomics dataset from 30 mouse gene knockouts and wildtypes, identifying 832 metabolites across multiple analytical methods.