Author

Steven Frucht

Mount Sinai Beth Israel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Aloysius DomingoiD· 2 shared Deborah RaymondiD· 2 shared Laurie J. OzeliusiD· 2 shared Rachel J. Saunders-PullmaniD· 2 shared Susan BressmaniD· 2 shared Adina H. WiseiD· 1 shared Alexander Chung· 1 shared Amanda AllaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Aloysius DomingoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Perisynaptic matrix gene variants underlie DystoniaGeneNet endophenotypes in isolated focal dystonia

Aloysius Domingo, Dongren Yao, Nyah Kshatriya, Kotchaphorn Mangkalaphiban, Giovanni Battistella, Lena C. O’Flynn, Bailey Reese, Madison Hincher, Rachita Yadav, Nutan Sharma, Laura Williams, Conor Fearon, Owen Killian, Richard B. Reilly, Michael Hutchinson, , Laurie J. Ozelius

This paper uses a deep learning model to identify genetic variants associated with isolated focal dystonia by leveraging neuroimaging endophenotypes.

medRxiv · Oct 21, 2026 · PreprintGenetic & Genomic Medicine

Integrated Stress Response Signatures Drive Monocyte Dysfunction in GBA1- and LRRK2-Linked Parkinson's Disease

Daniele Mattei, Erica Brophy, Mikaela Rosén, Oriol Narcis Majos, Aloysius Domingo, Elena Meijia, Claudia De Sanctis, Beomjin Jang, Tarek Khashan, Mengxi Yang, Deborah Raymond, Casey Young, Jack Humphrey, Elisa Navarro, Amanda Allan, , Towfique Raj

The paper identifies integrated stress response (ISR) signatures and proteostasis defects in monocytes from GBA1- and LRRK2-linked Parkinson's disease, linking them to immune dysfunction.

medRxiv · Oct 8, 2025 · PreprintGenetic & Genomic Medicine