Molecular Profiling and High-Content Drug Screening of Metastatic Colorectal Cancer Organoids Reveal Evolutionary Mechanisms of Pan-KRAS Inhibitor Resistance
Gizem Damla Yalçın, Kubra Celikbas Yilmaz, Raffaella Klima, Olcay Kurtulan, Düriye Özer Türkay, Oktay Halit Aktepe, Ahmet Bulent Dogrul, Cenk Sökmensüer, Volkan Öter, Erdal Birol Bostanci, Javier Fernández-Mateos, Suayib Yalcin, Luca Braga, Ahmet Acar
This study uses patient-derived organoids and single-cell RNA sequencing to investigate resistance mechanisms to pan-KRAS inhibitors in metastatic colorectal cancer.
bioRxiv · Jan 14, 2026 · PreprintCancer Biology