A Temporal and Spatial Atlas of Adaptive Immune Responses in the Lymph Node Following Viral Infection
Shaowen Jiang, Jahanara Freedman, Madhav Mantri, Viviana I. Maymí, Scott A. Leddon, Peter A. Schweitzer, Subash Bhandari, Chase Holdener, Ioannis Ntekas, Christopher Vollmers, Andrew I. Flyak, Deborah J. Fowell, Brian D. Rudd, Iwijn De Vlaminck
The paper introduces AIR-SPACE, a method combining spatial transcriptomics and immune receptor sequencing to map adaptive immune responses in lymph nodes post-viral infection, revealing spatial dynamics of immune cell activation and differentiation.
Proceedings of the National Academy of Sciences · Jan 26, 2026Peer-reviewedImmunology