CD4+ T-cells sensitize quasi-mesenchymal breast tumors lacking CD73 to anti-CTLA4 immune checkpoint blockade therapy
Shiney Chandraganti, Caitlyn Sams, Sarthak Sahoo, Brian Feng, Isabel O’Connell, Lynna Li, Sunita Nepal, Siddhartha Pulukuri, Kimaya M. Bakhle, Prathapan Thiru, Corina Simian, Viviana Maymi, Brian D. Rudd, George W. Bell, Stephen Hatfield, , Anushka Dongre
This study shows that targeting CD73 in quasi-mesenchymal breast tumors enhances their response to anti-CTLA4 therapy through CD4+ T-cell dependence.
Cancer Research Communications · May 12, 2026Peer-reviewedCancer Biology