Brian D. Rudd

This study shows that targeting CD73 in quasi-mesenchymal breast tumors enhances their response to anti-CTLA4 therapy through CD4+ T-cell dependence.

The paper identifies novel neonatal CD8β+ T cell subsets (FITs) with innate-like features, distinct from conventional and unconventional T cells, using cord blood samples.

The paper introduces AIR-SPACE, a method combining spatial transcriptomics and immune receptor sequencing to map adaptive immune responses in lymph nodes post-viral infection, revealing spatial dynamics of immune cell activation and differentiation.

This study constructs a transcriptional and epigenetic atlas of T cell development in neonatal and adult mice, identifying age-related gene regulatory programs and a conserved regulator, Zbtb20.

A single amino acid substitution in CD28 enhances signaling, leading to increased CD8 activation and Tpex generation during viral infection, while accelerating exhaustion in chronic infection.

This study compares neonatal and adult CD8+ recent thymic emigrants using single-cell multiomics, finding distinct phenotypes and functions despite similar post-thymic maturation.

This study shows that recent thymic emigrants are preferentially recruited into the memory pool during persistent CMV infection, while mature CD8+ T cells contribute little.

The paper identifies gene regulatory programs distinguishing naive CD8+ T cell subsets using RNA-seq and ATAC-seq data, revealing novel regulators and transcriptional networks.

This paper analyzes single-cell transcriptomes from mouse skeletal muscle across lifespan to identify age-related changes in stem cell states and senescence associated with impaired regeneration.