Jahanara Freedman

The paper introduces AIR-SPACE, a method combining spatial transcriptomics and immune receptor sequencing to map adaptive immune responses in lymph nodes post-viral infection, revealing spatial dynamics of immune cell activation and differentiation.

Compressed Perturb-seq reduces cost and complexity of CRISPR screens by using random composite perturbations and computational decomposition, achieving similar accuracy to conventional methods with greater power to detect genetic interactions.