Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria
Rafael B. Polidoro, Olivia J. Bednarski, Samuel M. Lehman, Fabrício Marcus Silva Oliveira, Elizabeth M. Fusco, Layne K. Bower, Marcos Vinícius Rangel-Ferreira, Sukhmeet Kour, Ruth Namazzi, Robert Opika Opoka, Chandy C. John, Jeffrey J. Brault, Andrew Tilston-Lünel, JC Alves‐Filho, Nathan W. Schmidt
This study shows that gut barrier loss during malaria allows microbiota to trigger purinergic immunosuppression, leading to severe disease.
bioRxiv · Jan 24, 2026 · PreprintImmunology