José Carlos Alves-Filho

Targeting soluble immunoglobulins ameliorates idiopathic multicentric Castleman disease in a mouse model

This paper develops a mouse model of idiopathic multicentric Castleman disease (iMCD) by targeting IL-6 to Foxp3+ Treg cells, showing that reducing soluble immunoglobulin production alleviates disease symptoms and improves survival.

GALR2 W248L mutation exacerbates neuroinflammation through pro-inflammatory macrophage polarization and microglial activation in experimental autoimmune encephalomyelitis

This study shows that the GALR2 W248L mutation worsens neuroinflammation by promoting pro-inflammatory macrophage polarization and microglial activation in EAE.

Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria

This study shows that gut barrier loss during malaria allows microbiota to trigger purinergic immunosuppression, leading to severe disease.

Escherichia coli-induced gut IL-33 release inhibits lung type 2 allergic responses

This study shows that exposure to ETEC or its toxin LT reduces lung allergic inflammation by inhibiting IL-33 responses in ILC2 cells through a gut-derived negative feedback loop.

A central role for CCR2 in monocyte recruitment and blood-brain barrier disruption during Usutu virus encephalitis

This study identifies CCR2 as critical for monocyte recruitment and BBB disruption in USUV encephalitis, showing therapeutic benefit from glucocorticoid treatment.

Differential action modes of Neutrophil Extracellular Trap-targeted drugs define T cell responses in SARS-CoV-2 infection.

This study compares how two NET-targeting drugs, rhDNase and GSK484, affect T cell responses in SARS-CoV-2 infection, showing differing impacts on adaptive immunity.

Meningeal dendritic cells-astrocytes interactions elevate the kynurenine metabolic pathway to sustain neuropathic pain

This study identifies the kynurenine metabolic pathway as a key factor in sustaining neuropathic pain through interactions between meningeal dendritic cells and astrocytes.