Jeffrey J. Brault

The paper identifies ADSS1 as a suppressed metabolic control node in dystrophic muscle, showing its role in purine metabolism and its impact on inflammatory and adipogenic remodelling.

This study shows that gut barrier loss during malaria allows microbiota to trigger purinergic immunosuppression, leading to severe disease.

This paper presents a mouse model of ADSS1 myopathy by knocking out Adss1 and characterizes its motor deficits and histopathological features.

This study shows that Tafazzin deficiency in skeletal muscle causes neuromuscular remodeling, including fiber type shifts and motor unit loss, without resting energetic failure.