Ashish Ganeshlalji Toshniwal

This study shows that lactate can be directly imported into mitochondria and oxidized to support cardiac energy production, independent of the pyruvate carrier.

This study compares the effects of tirzepatide and caloric restriction on hematopoiesis in obese mice, finding tirzepatide preserves HSPC cycling and reduces inflammatory monocytes while CR causes cytopenias.

The paper shows that pyruvate metabolism affects cell growth in post-mitotic cells by altering redox balance and metabolic pathways, despite active growth signals.