Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF
Anam Fatima, Faris Abusharkh, Zoe Zanetta, Sumner Gardner, Fubiao Shi, Elizabeth Kobeck, Niki L. Fortune, Tuerdi Subati, Katherine N. Bachmann, Jonathan D. Brown, Deepak K. Gupta, David Armstrong, Jean W. Wassenaar, James D. West, Evan L. Brittain, , Vineet Agrawal
This study identifies a novel crosstalk mechanism between cardiomyocytes and adipocytes in obesity-associated HFpEF driven by natriuretic peptide-mediated inhibition of Wnt5a release from adipocytes.
bioRxiv · Oct 29, 2025 · PreprintMolecular Biology