Author

James D. West

Vanderbilt UniversityORCID 0000-0002-6004-0202Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1

Frequent Co-Authors

Elizabeth Kobeck· 2 shared Santhi Gladson· 2 shared Vineet AgrawaliD· 2 shared Anam FatimaiD· 1 shared Ananya ChakrabortyiD· 1 shared Ankita MitraiD· 1 shared Anna R. Hemnes· 1 shared Anna Ryan HemnesiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Elizabeth Kobeck

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION

Stuti Agarwal, Anuradha Bankar, Lyong Heo, Ankita Mitra, Ananya Chakraborty, Lichao Liu, Flora Huang, Gowri Swaminathan, Natasha Auer, Prakash Chelladurai, Eleana Stephanie Guardado, J. A. Matos, Crystal Le, James West, Karthik Suresh, , Vinicio de Jesús Pérez

This study identifies CES1 deficiency as a driver of metabolic reprogramming and endothelial dysfunction in pulmonary arterial hypertension, showing its role in lipid metabolism and oxidative stress.

American Journal of Respiratory and Critical Care Medicine · Feb 18, 2026Peer-reviewedBiochemistry

Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF

Anam Fatima, Faris Abusharkh, Zoe Zanetta, Sumner Gardner, Fubiao Shi, Elizabeth Kobeck, Niki L. Fortune, Tuerdi Subati, Katherine N. Bachmann, Jonathan D. Brown, Deepak K. Gupta, David Armstrong, Jean W. Wassenaar, James D. West, Evan L. Brittain, , Vineet Agrawal

This study identifies a novel crosstalk mechanism between cardiomyocytes and adipocytes in obesity-associated HFpEF driven by natriuretic peptide-mediated inhibition of Wnt5a release from adipocytes.

bioRxiv · Oct 29, 2025 · PreprintMolecular Biology

Reducing Reactive Lipids Improves Cardiac Metabolic and Diastolic Function in Pulmonary Hypertension Models

James D. West, Christy Moore, Santhi Gladson, Sheila Shay, Ethan Sevier, Elizabeth Kobeck, Ying Cai, Vineet Agrawal, John A. Rathmacher, Anna R. Hemnes

This study shows that reducing reactive lipids with 2-HOBA improves cardiac function and reduces pulmonary hypertension in mouse models.

bioRxiv · Oct 10, 2025Molecular Biology

Saracatinib and Dasatinib Fail To Prevent Heritable Pulmonary Arterial Hypertension

Reid D’Amico, Santhi Gladson, Sheila D. Shay, Courtney A. Copeland, James D. West

This study tests if SRC inhibition prevents heritable pulmonary arterial hypertension in BMPR2 mutant mice, finding it ineffective.

bioRxiv · Jun 12, 2018 · PreprintMolecular Biology