This study identifies a novel crosstalk mechanism between cardiomyocytes and adipocytes in obesity-associated HFpEF driven by natriuretic peptide-mediated inhibition of Wnt5a release from adipocytes.

bioRxiv · Oct 29, 2025 · PreprintMolecular Biology

The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity

Emeli Chatterjee, Michael J. Betti, Quanhu Sheng, Phillip Lin, Margo P. Emont, Guoping Li, Kaushik V Amancherla, Marta García-Contreras, Priyanka Gokulnath, Worawan B. Limpitikul, Olivia Rosina Whittaker, Kathy Luong, Christopher Azzam, Denise W. Gee, Matthew Hutter, , Saumya Das

The paper identifies obesity-related transcriptional changes in circulating extracellular vesicles and links them to adipose tissue epigenetics and inflammatory disease risk.

Cell Genomics · Jul 16, 2025Peer-reviewedGenetic & Genomic Medicine

The transcription factor ZNF469 regulates collagen production in liver fibrosis

Sebastian Steinhauser, David Estoppey, Dennis P. Buehler, Yanhua Xiong, Nicolas Pizzato, Amandine Rietsch, Fabian Wu, Nelly Leroy, Tiffany Wunderlin, Isabelle Claerr, Philipp Tropberger, Miriam J. Müller, Alexandra Vissières, Lindsay M. Davison, Eric H. Farber‐Eger, , Christian Kolter

The paper identifies ZNF469 as a transcription factor regulating collagen production in liver fibrosis through computational analysis and experimental validation.

JCI Insight · Feb 25, 2025Peer-reviewedMolecular Biology

Erythropoietin regulates transcription and YY1 dynamics in a pre-established chromatin architecture

Andrea A. Perreault, Jonathan D. Brown, Bryan J. Venters

The paper studies how erythropoietin (EPO) affects transcription and YY1 dynamics within a fixed chromatin structure during erythropoiesis.

iScience · Jan 1, 2020Peer-reviewedMolecular Biology