Coronavirus papain-like protease antagonizes innate immunity by cleaving Importin α1 to disrupt nuclear transport
王皆欢, Wenxiang Xue, Sun YingJie, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding, Ying Liao
This paper identifies that coronavirus PLpro-TM cleaves Importin α1 to disrupt nuclear transport and suppress antiviral immunity, revealing a conserved immune evasion strategy across coronaviruses.
bioRxiv · Jul 20, 2026 · PreprintMicrobiology