Ying Liao

Oncolytic Newcastle disease virus promotes tumor cell apoptosis through SUMO-1-dependent PRKN-mediated degradation of c-Myc

Coronavirus papain-like protease antagonizes innate immunity by cleaving Importin α1 to disrupt nuclear transport

This paper identifies that coronavirus PLpro-TM cleaves Importin α1 to disrupt nuclear transport and suppress antiviral immunity, revealing a conserved immune evasion strategy across coronaviruses.

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication

This study identifies DAZAP2 as a pan-coronavirus restriction factor that inhibits viral entry and genomic replication, with physiological relevance confirmed in mouse models and human cells.

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

Infectious bronchitis virus attaches to lipid rafts and enters cells via clathrin mediated endocytosis

This study identifies the molecular mechanisms of infectious bronchitis virus (IBV) entry, showing it attaches to lipid rafts and enters via clathrin-mediated endocytosis, followed by endosomal trafficking and membrane fusion.