Kidney cystogenesis in embryonic- and adult-onset ADPKD is suppressed from lack of adenylyl cyclase targeting to cilia
Sun-Hee Hwang, Kyungsuk Choi, Hemant Badgandi, Kevin A. White, Yu Xun, Owen M. Woodward, Feng Qian, Saikat Mukhopadhyay
This study identifies ANKMY2's role in ciliary adenylyl cyclase trafficking, showing its suppression reduces cystogenesis in ADPKD models without affecting cAMP levels or cilia structure.
PLoS Genetics · Dec 31, 2025Peer-reviewedCell Biology