Owen M. Woodward

The paper develops a transcriptome-based method to match bulk RNA-seq data from kidney cell lines to single-cell reference datasets, identifying accurate cell type identities and evaluating method performance.

This study identifies ANKMY2's role in ciliary adenylyl cyclase trafficking, showing its suppression reduces cystogenesis in ADPKD models without affecting cAMP levels or cilia structure.

This study identifies an extra-ciliary role for polycystins in regulating Ezrin and renal tubular morphology through phosphorylation and localization changes.

This study uses single-nucleus multi-omics to analyze mouse PKD progression, identifying cell-type-specific gene and epigenetic changes and conserved regulatory pathways between mouse and human.

This study uses single-cell multiomic analysis to define cellular complexity in ADPKD, identifying novel transcriptomic and epigenomic features in cystic kidney cells.