Discovery of a Small-Molecule mTORC1 Pathway Activator that Enhances Adoptive T-Cell Therapy via Immuno-metabolic Reprogramming of CD8+ T Cells
Dipika Sarkar, Puspendu Ghosh, Sunny Goon, Ishita Sarkar, Himadri Sekhar Sarkar, Deborpita Sarkar, Anupam Goutam, Shaun Mahanti, Sandip Paul, Shilpak Chatterjee, Arindam Talukdar
This paper identifies AS-3, a small-molecule activator of mTORC1 that enhances CD8 T cell function and antitumor efficacy in adoptive cell therapy.
bioRxiv · Sep 16, 2026 · PreprintImmunology