In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales
Jieming Chen, Shravan Madireddi, Deepti R. Nagarkar, Maciej Migdał, Jason A. Vander Heiden, Diana Chang, Kiran Mukhyala, Suresh K. Selvaraj, Edward Ernest Kadel, Matthew J. Brauer, Sanjeev Mariathasan, Julie Hunkapiller, Suchit Jhunjhunwala, Matthew L. Albert, Christian Hammer
The paper evaluates computational tools for accurately inferring HLA alleles and KIR haplotypes from whole-genome or whole-exome sequencing data, showing high accuracy for both tasks.
Briefings in Bioinformatics · Aug 20, 2020Peer-reviewedBioinformatics