Christian Hammer

TumorLens detects genetic and epigenetic alterations in cancer using long reads, revealing key somatic events and methylation patterns across tumor samples.

The paper identifies genetically distinct patient subgroups across diseases by analyzing polygenic risk and pathway convergence.

This study identifies three germline variants associated with immune-related adverse events in patients treated with immune checkpoint inhibitors.

This study identifies HLA-DRB1 and HLA-DQA1 alleles associated with anti-drug antibodies and neutralizing antibodies in atezolizumab-treated cancer patients.

This study identifies sex-dependent genetic risk loci shared and specific to mood and psychotic disorders using genome-wide interaction analysis.

MiDAS is an R package that enables statistical analysis of immunogenetic data, including HLA fine mapping, evolutionary divergence, and HLA-KIR interactions.

The paper compares ten polygenic score methods for psychiatric disorders across multiple cohorts, finding that some methods significantly improve prediction statistics over the baseline PC+T method.

The paper investigates how human genetic variation influences Epstein-Barr virus (EBV) sequence diversity by analyzing paired viral and human genomic data from HIV-coinfected individuals.

The paper evaluates computational tools for accurately inferring HLA alleles and KIR haplotypes from whole-genome or whole-exome sequencing data, showing high accuracy for both tasks.

This study identifies a genetic variant near CXCL12 associated with increased susceptibility to HIV-related non-Hodgkin lymphoma.

The paper shows that polygenic risk scores for skin autoimmunity affect the response to immune checkpoint blockade in bladder cancer, with higher vitiligo and psoriasis scores linked to better outcomes.

This study identifies non-genetic factors associated with gut microbiome diversity in a cohort of healthy individuals, finding no genome-wide significant genetic associations.

This study uses exome sequencing to investigate genetic factors contributing to acute liver failure from HBV infection in liver transplant recipients but finds no causal variants.

The paper shows that correcting for population stratification in host and pathogen genomes reduces false positives and negatives in association analyses.

This study identifies age, sex, and genetic variants as key predictors of variability in humoral immune responses to pathogens and vaccines.

The paper finds a genetic association between schizophrenia risk and age at first birth in women, with different genetic correlations in younger and older age groups.

This study compares LDSC and GREML methods for estimating genetic correlation, showing GREML provides higher accuracy, especially in the presence of genetic heterogeneity.