Jason A. Vander Heiden

This study shows that blocking OSM and IL-6 reduces fibrosis and inflammation in pulmonary fibrosis by targeting their shared receptor and distinct pathways.

This study identifies Dpt+ fibroblasts as essential for maintaining a Csf1-dependent macrophage niche in skin, with implications for wound healing and scleroderma.

The paper introduces SCimilarity, a metric learning framework for querying and comparing single-cell RNA-seq data across the human body, revealing commonalities in fibrosis-associated macrophages.

The paper evaluates computational tools for accurately inferring HLA alleles and KIR haplotypes from whole-genome or whole-exome sequencing data, showing high accuracy for both tasks.

The paper improves the TIgGER algorithm to accurately identify subject-specific immunoglobulin alleles from AIRR-seq data, even when alleles differ by more than 5 SNPs from known database alleles.